Oxidative stress in patients with clinically mild encephalitis/encephalopathy with a reversible splenial lesion (MERS).
Identifieur interne : 002226 ( Main/Exploration ); précédent : 002225; suivant : 002227Oxidative stress in patients with clinically mild encephalitis/encephalopathy with a reversible splenial lesion (MERS).
Auteurs : Rie Miyata [Japon] ; Naoyuki Tanuma ; Masaharu Hayashi ; Takuji Imamura ; Jun-Ichi Takanashi ; Rieko Nagata ; Akihisa Okumura ; Hirohumi Kashii ; Sunao Tomita ; Satoko Kumada ; Masaya KubotaSource :
- Brain & development [ 1872-7131 ] ; 2012.
Descripteurs français
- KwdFr :
- Adolescent, Corps calleux (anatomopathologie), Corps calleux (métabolisme), Cytokines (), Dosage radioimmunologique, Désoxyguanosine (), Désoxyguanosine (analogues et dérivés), Encéphalite (), Encéphalite (sang), Encéphalopathies (), Encéphalopathies (anatomopathologie), Encéphalopathies (sang), Enfant, Enfant d'âge préscolaire, Enolase (métabolisme), Femelle, Humains, Imagerie par résonance magnétique, Mâle, Nourrisson, Protéines tau (), Sodium (sang), Stress oxydatif (physiologie), Test ELISA.
- MESH :
- analogues et dérivés : Désoxyguanosine.
- anatomopathologie : Corps calleux, Encéphalopathies.
- métabolisme : Corps calleux, Enolase.
- physiologie : Stress oxydatif.
- sang : Encéphalite, Encéphalopathies, Sodium.
- Adolescent, Cytokines, Dosage radioimmunologique, Désoxyguanosine, Encéphalite, Encéphalopathies, Enfant, Enfant d'âge préscolaire, Femelle, Humains, Imagerie par résonance magnétique, Mâle, Nourrisson, Protéines tau, Test ELISA.
English descriptors
- KwdEn :
- 8-Hydroxy-2'-Deoxyguanosine, Adolescent, Brain Diseases (blood), Brain Diseases (cerebrospinal fluid), Brain Diseases (complications), Brain Diseases (pathology), Child, Child, Preschool, Corpus Callosum (metabolism), Corpus Callosum (pathology), Cytokines (cerebrospinal fluid), Deoxyguanosine (analogs & derivatives), Deoxyguanosine (cerebrospinal fluid), Encephalitis (blood), Encephalitis (cerebrospinal fluid), Encephalitis (complications), Enzyme-Linked Immunosorbent Assay, Female, Humans, Infant, Magnetic Resonance Imaging, Male, Oxidative Stress (physiology), Phosphopyruvate Hydratase (metabolism), Radioimmunoassay, Sodium (blood), tau Proteins (cerebrospinal fluid).
- MESH :
- chemical , analogs & derivatives : Deoxyguanosine.
- chemical , blood : Sodium.
- chemical , cerebrospinal fluid : Cytokines, Deoxyguanosine, tau Proteins.
- chemical , metabolism : Phosphopyruvate Hydratase.
- chemical : 8-Hydroxy-2'-Deoxyguanosine.
- blood : Brain Diseases, Encephalitis.
- cerebrospinal fluid : Brain Diseases, Encephalitis.
- complications : Brain Diseases, Encephalitis.
- metabolism : Corpus Callosum.
- pathology : Brain Diseases, Corpus Callosum.
- physiology : Oxidative Stress.
- Adolescent, Child, Child, Preschool, Enzyme-Linked Immunosorbent Assay, Female, Humans, Infant, Magnetic Resonance Imaging, Male, Radioimmunoassay.
Abstract
We examined oxidative stress markers, tau protein and cytokines in the cerebrospinal fluid (CSF) in six patients with clinically mild encephalitis/encephalopathy with a reversible splenial lesion (MERS). In the CSF, 8-hydroxy-2'-deoxyguanosine (8-OHdG) and hexanoyl-lysine adduct levels increased over the cutoff index in four and one out of six MERS patients, respectively. The CSF IL-6 and IL-10 levels were increased in three out of six patients, two of which had extended lesion of the cerebral white matter. The CSF value of tau protein, marker of the axonal damage, was not increased, and neuron specific enolase (NSE) in the CSF was not increased. The increased 8-OHdG levels in the CSF, DNA oxidative stress marker, in four MERS patients, suggesting involvement of oxidative stress in MERS. MERS is occasionally accompanied with hyponatremia, although our patients lacked hyponatremia. It is possible that the disequilibrium of systemic metabolism including electrolytes may lead to facilitation of oxidative stress and reversible white matter lesion in MERS. The increase of cytokine production seems to be involved in the distribution of lesions in MERS.
DOI: 10.1016/j.braindev.2011.04.004
PubMed: 21576007
Affiliations:
Links toward previous steps (curation, corpus...)
- to stream PubMed, to step Corpus: 001E79
- to stream PubMed, to step Curation: 001E79
- to stream PubMed, to step Checkpoint: 001C52
- to stream Ncbi, to step Merge: 000834
- to stream Ncbi, to step Curation: 000834
- to stream Ncbi, to step Checkpoint: 000834
- to stream Main, to step Merge: 002251
- to stream Main, to step Curation: 002226
Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Oxidative stress in patients with clinically mild encephalitis/encephalopathy with a reversible splenial lesion (MERS).</title>
<author><name sortKey="Miyata, Rie" sort="Miyata, Rie" uniqKey="Miyata R" first="Rie" last="Miyata">Rie Miyata</name>
<affiliation wicri:level="3"><nlm:affiliation>Department of Pediatrics, Tokyo-Kita Social Insurance Hospital, Kita-ku, Tokyo, Japan. rie88miyata@ybb.ne.jp</nlm:affiliation>
<country xml:lang="fr">Japon</country>
<wicri:regionArea>Department of Pediatrics, Tokyo-Kita Social Insurance Hospital, Kita-ku, Tokyo</wicri:regionArea>
<placeName><settlement type="city">Tokyo</settlement>
<region type="région">Région de Kantō</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Tanuma, Naoyuki" sort="Tanuma, Naoyuki" uniqKey="Tanuma N" first="Naoyuki" last="Tanuma">Naoyuki Tanuma</name>
</author>
<author><name sortKey="Hayashi, Masaharu" sort="Hayashi, Masaharu" uniqKey="Hayashi M" first="Masaharu" last="Hayashi">Masaharu Hayashi</name>
</author>
<author><name sortKey="Imamura, Takuji" sort="Imamura, Takuji" uniqKey="Imamura T" first="Takuji" last="Imamura">Takuji Imamura</name>
</author>
<author><name sortKey="Takanashi, Jun Ichi" sort="Takanashi, Jun Ichi" uniqKey="Takanashi J" first="Jun-Ichi" last="Takanashi">Jun-Ichi Takanashi</name>
</author>
<author><name sortKey="Nagata, Rieko" sort="Nagata, Rieko" uniqKey="Nagata R" first="Rieko" last="Nagata">Rieko Nagata</name>
</author>
<author><name sortKey="Okumura, Akihisa" sort="Okumura, Akihisa" uniqKey="Okumura A" first="Akihisa" last="Okumura">Akihisa Okumura</name>
</author>
<author><name sortKey="Kashii, Hirohumi" sort="Kashii, Hirohumi" uniqKey="Kashii H" first="Hirohumi" last="Kashii">Hirohumi Kashii</name>
</author>
<author><name sortKey="Tomita, Sunao" sort="Tomita, Sunao" uniqKey="Tomita S" first="Sunao" last="Tomita">Sunao Tomita</name>
</author>
<author><name sortKey="Kumada, Satoko" sort="Kumada, Satoko" uniqKey="Kumada S" first="Satoko" last="Kumada">Satoko Kumada</name>
</author>
<author><name sortKey="Kubota, Masaya" sort="Kubota, Masaya" uniqKey="Kubota M" first="Masaya" last="Kubota">Masaya Kubota</name>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">PubMed</idno>
<date when="2012">2012</date>
<idno type="RBID">pubmed:21576007</idno>
<idno type="pmid">21576007</idno>
<idno type="doi">10.1016/j.braindev.2011.04.004</idno>
<idno type="wicri:Area/PubMed/Corpus">001E79</idno>
<idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">001E79</idno>
<idno type="wicri:Area/PubMed/Curation">001E79</idno>
<idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">001E79</idno>
<idno type="wicri:Area/PubMed/Checkpoint">001C52</idno>
<idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">001C52</idno>
<idno type="wicri:Area/Ncbi/Merge">000834</idno>
<idno type="wicri:Area/Ncbi/Curation">000834</idno>
<idno type="wicri:Area/Ncbi/Checkpoint">000834</idno>
<idno type="wicri:Area/Main/Merge">002251</idno>
<idno type="wicri:Area/Main/Curation">002226</idno>
<idno type="wicri:Area/Main/Exploration">002226</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title xml:lang="en">Oxidative stress in patients with clinically mild encephalitis/encephalopathy with a reversible splenial lesion (MERS).</title>
<author><name sortKey="Miyata, Rie" sort="Miyata, Rie" uniqKey="Miyata R" first="Rie" last="Miyata">Rie Miyata</name>
<affiliation wicri:level="3"><nlm:affiliation>Department of Pediatrics, Tokyo-Kita Social Insurance Hospital, Kita-ku, Tokyo, Japan. rie88miyata@ybb.ne.jp</nlm:affiliation>
<country xml:lang="fr">Japon</country>
<wicri:regionArea>Department of Pediatrics, Tokyo-Kita Social Insurance Hospital, Kita-ku, Tokyo</wicri:regionArea>
<placeName><settlement type="city">Tokyo</settlement>
<region type="région">Région de Kantō</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Tanuma, Naoyuki" sort="Tanuma, Naoyuki" uniqKey="Tanuma N" first="Naoyuki" last="Tanuma">Naoyuki Tanuma</name>
</author>
<author><name sortKey="Hayashi, Masaharu" sort="Hayashi, Masaharu" uniqKey="Hayashi M" first="Masaharu" last="Hayashi">Masaharu Hayashi</name>
</author>
<author><name sortKey="Imamura, Takuji" sort="Imamura, Takuji" uniqKey="Imamura T" first="Takuji" last="Imamura">Takuji Imamura</name>
</author>
<author><name sortKey="Takanashi, Jun Ichi" sort="Takanashi, Jun Ichi" uniqKey="Takanashi J" first="Jun-Ichi" last="Takanashi">Jun-Ichi Takanashi</name>
</author>
<author><name sortKey="Nagata, Rieko" sort="Nagata, Rieko" uniqKey="Nagata R" first="Rieko" last="Nagata">Rieko Nagata</name>
</author>
<author><name sortKey="Okumura, Akihisa" sort="Okumura, Akihisa" uniqKey="Okumura A" first="Akihisa" last="Okumura">Akihisa Okumura</name>
</author>
<author><name sortKey="Kashii, Hirohumi" sort="Kashii, Hirohumi" uniqKey="Kashii H" first="Hirohumi" last="Kashii">Hirohumi Kashii</name>
</author>
<author><name sortKey="Tomita, Sunao" sort="Tomita, Sunao" uniqKey="Tomita S" first="Sunao" last="Tomita">Sunao Tomita</name>
</author>
<author><name sortKey="Kumada, Satoko" sort="Kumada, Satoko" uniqKey="Kumada S" first="Satoko" last="Kumada">Satoko Kumada</name>
</author>
<author><name sortKey="Kubota, Masaya" sort="Kubota, Masaya" uniqKey="Kubota M" first="Masaya" last="Kubota">Masaya Kubota</name>
</author>
</analytic>
<series><title level="j">Brain & development</title>
<idno type="eISSN">1872-7131</idno>
<imprint><date when="2012" type="published">2012</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>8-Hydroxy-2'-Deoxyguanosine</term>
<term>Adolescent</term>
<term>Brain Diseases (blood)</term>
<term>Brain Diseases (cerebrospinal fluid)</term>
<term>Brain Diseases (complications)</term>
<term>Brain Diseases (pathology)</term>
<term>Child</term>
<term>Child, Preschool</term>
<term>Corpus Callosum (metabolism)</term>
<term>Corpus Callosum (pathology)</term>
<term>Cytokines (cerebrospinal fluid)</term>
<term>Deoxyguanosine (analogs & derivatives)</term>
<term>Deoxyguanosine (cerebrospinal fluid)</term>
<term>Encephalitis (blood)</term>
<term>Encephalitis (cerebrospinal fluid)</term>
<term>Encephalitis (complications)</term>
<term>Enzyme-Linked Immunosorbent Assay</term>
<term>Female</term>
<term>Humans</term>
<term>Infant</term>
<term>Magnetic Resonance Imaging</term>
<term>Male</term>
<term>Oxidative Stress (physiology)</term>
<term>Phosphopyruvate Hydratase (metabolism)</term>
<term>Radioimmunoassay</term>
<term>Sodium (blood)</term>
<term>tau Proteins (cerebrospinal fluid)</term>
</keywords>
<keywords scheme="KwdFr" xml:lang="fr"><term>Adolescent</term>
<term>Corps calleux (anatomopathologie)</term>
<term>Corps calleux (métabolisme)</term>
<term>Cytokines ()</term>
<term>Dosage radioimmunologique</term>
<term>Désoxyguanosine ()</term>
<term>Désoxyguanosine (analogues et dérivés)</term>
<term>Encéphalite ()</term>
<term>Encéphalite (sang)</term>
<term>Encéphalopathies ()</term>
<term>Encéphalopathies (anatomopathologie)</term>
<term>Encéphalopathies (sang)</term>
<term>Enfant</term>
<term>Enfant d'âge préscolaire</term>
<term>Enolase (métabolisme)</term>
<term>Femelle</term>
<term>Humains</term>
<term>Imagerie par résonance magnétique</term>
<term>Mâle</term>
<term>Nourrisson</term>
<term>Protéines tau ()</term>
<term>Sodium (sang)</term>
<term>Stress oxydatif (physiologie)</term>
<term>Test ELISA</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="analogs & derivatives" xml:lang="en"><term>Deoxyguanosine</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="blood" xml:lang="en"><term>Sodium</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="cerebrospinal fluid" xml:lang="en"><term>Cytokines</term>
<term>Deoxyguanosine</term>
<term>tau Proteins</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Phosphopyruvate Hydratase</term>
</keywords>
<keywords scheme="MESH" type="chemical" xml:lang="en"><term>8-Hydroxy-2'-Deoxyguanosine</term>
</keywords>
<keywords scheme="MESH" qualifier="analogues et dérivés" xml:lang="fr"><term>Désoxyguanosine</term>
</keywords>
<keywords scheme="MESH" qualifier="anatomopathologie" xml:lang="fr"><term>Corps calleux</term>
<term>Encéphalopathies</term>
</keywords>
<keywords scheme="MESH" qualifier="blood" xml:lang="en"><term>Brain Diseases</term>
<term>Encephalitis</term>
</keywords>
<keywords scheme="MESH" qualifier="cerebrospinal fluid" xml:lang="en"><term>Brain Diseases</term>
<term>Encephalitis</term>
</keywords>
<keywords scheme="MESH" qualifier="complications" xml:lang="en"><term>Brain Diseases</term>
<term>Encephalitis</term>
</keywords>
<keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>Corpus Callosum</term>
</keywords>
<keywords scheme="MESH" qualifier="métabolisme" xml:lang="fr"><term>Corps calleux</term>
<term>Enolase</term>
</keywords>
<keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Brain Diseases</term>
<term>Corpus Callosum</term>
</keywords>
<keywords scheme="MESH" qualifier="physiologie" xml:lang="fr"><term>Stress oxydatif</term>
</keywords>
<keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Oxidative Stress</term>
</keywords>
<keywords scheme="MESH" qualifier="sang" xml:lang="fr"><term>Encéphalite</term>
<term>Encéphalopathies</term>
<term>Sodium</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Adolescent</term>
<term>Child</term>
<term>Child, Preschool</term>
<term>Enzyme-Linked Immunosorbent Assay</term>
<term>Female</term>
<term>Humans</term>
<term>Infant</term>
<term>Magnetic Resonance Imaging</term>
<term>Male</term>
<term>Radioimmunoassay</term>
</keywords>
<keywords scheme="MESH" xml:lang="fr"><term>Adolescent</term>
<term>Cytokines</term>
<term>Dosage radioimmunologique</term>
<term>Désoxyguanosine</term>
<term>Encéphalite</term>
<term>Encéphalopathies</term>
<term>Enfant</term>
<term>Enfant d'âge préscolaire</term>
<term>Femelle</term>
<term>Humains</term>
<term>Imagerie par résonance magnétique</term>
<term>Mâle</term>
<term>Nourrisson</term>
<term>Protéines tau</term>
<term>Test ELISA</term>
</keywords>
</textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en">We examined oxidative stress markers, tau protein and cytokines in the cerebrospinal fluid (CSF) in six patients with clinically mild encephalitis/encephalopathy with a reversible splenial lesion (MERS). In the CSF, 8-hydroxy-2'-deoxyguanosine (8-OHdG) and hexanoyl-lysine adduct levels increased over the cutoff index in four and one out of six MERS patients, respectively. The CSF IL-6 and IL-10 levels were increased in three out of six patients, two of which had extended lesion of the cerebral white matter. The CSF value of tau protein, marker of the axonal damage, was not increased, and neuron specific enolase (NSE) in the CSF was not increased. The increased 8-OHdG levels in the CSF, DNA oxidative stress marker, in four MERS patients, suggesting involvement of oxidative stress in MERS. MERS is occasionally accompanied with hyponatremia, although our patients lacked hyponatremia. It is possible that the disequilibrium of systemic metabolism including electrolytes may lead to facilitation of oxidative stress and reversible white matter lesion in MERS. The increase of cytokine production seems to be involved in the distribution of lesions in MERS.</div>
</front>
</TEI>
<affiliations><list><country><li>Japon</li>
</country>
<region><li>Région de Kantō</li>
</region>
<settlement><li>Tokyo</li>
</settlement>
</list>
<tree><noCountry><name sortKey="Hayashi, Masaharu" sort="Hayashi, Masaharu" uniqKey="Hayashi M" first="Masaharu" last="Hayashi">Masaharu Hayashi</name>
<name sortKey="Imamura, Takuji" sort="Imamura, Takuji" uniqKey="Imamura T" first="Takuji" last="Imamura">Takuji Imamura</name>
<name sortKey="Kashii, Hirohumi" sort="Kashii, Hirohumi" uniqKey="Kashii H" first="Hirohumi" last="Kashii">Hirohumi Kashii</name>
<name sortKey="Kubota, Masaya" sort="Kubota, Masaya" uniqKey="Kubota M" first="Masaya" last="Kubota">Masaya Kubota</name>
<name sortKey="Kumada, Satoko" sort="Kumada, Satoko" uniqKey="Kumada S" first="Satoko" last="Kumada">Satoko Kumada</name>
<name sortKey="Nagata, Rieko" sort="Nagata, Rieko" uniqKey="Nagata R" first="Rieko" last="Nagata">Rieko Nagata</name>
<name sortKey="Okumura, Akihisa" sort="Okumura, Akihisa" uniqKey="Okumura A" first="Akihisa" last="Okumura">Akihisa Okumura</name>
<name sortKey="Takanashi, Jun Ichi" sort="Takanashi, Jun Ichi" uniqKey="Takanashi J" first="Jun-Ichi" last="Takanashi">Jun-Ichi Takanashi</name>
<name sortKey="Tanuma, Naoyuki" sort="Tanuma, Naoyuki" uniqKey="Tanuma N" first="Naoyuki" last="Tanuma">Naoyuki Tanuma</name>
<name sortKey="Tomita, Sunao" sort="Tomita, Sunao" uniqKey="Tomita S" first="Sunao" last="Tomita">Sunao Tomita</name>
</noCountry>
<country name="Japon"><region name="Région de Kantō"><name sortKey="Miyata, Rie" sort="Miyata, Rie" uniqKey="Miyata R" first="Rie" last="Miyata">Rie Miyata</name>
</region>
</country>
</tree>
</affiliations>
</record>
Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Sante/explor/MersV1/Data/Main/Exploration
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 002226 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 002226 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien |wiki= Sante |area= MersV1 |flux= Main |étape= Exploration |type= RBID |clé= pubmed:21576007 |texte= Oxidative stress in patients with clinically mild encephalitis/encephalopathy with a reversible splenial lesion (MERS). }}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/Main/Exploration/RBID.i -Sk "pubmed:21576007" \ | HfdSelect -Kh $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd \ | NlmPubMed2Wicri -a MersV1
This area was generated with Dilib version V0.6.33. |